Milk fat globule—epidermal growth factor—factor VIII (MFGE8)/lactadherin promotes bladder tumor development
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منابع مشابه
Overexpression of epidermal growth factor receptor in urothelium elicits urothelial hyperplasia and promotes bladder tumor growth.
Although urothelium is constantly bathed in high concentrations of epidermal growth factor (EGF) and most urothelial carcinomas overexpress EGF receptor (EGFr), relatively little is known about the role of EGFr signaling pathway in urothelial growth and transformation. In the present study, we used the uroplakin II gene promoter to drive the urothelial overexpression of EGFr in transgenic mice....
متن کاملBladder Tumor Growth Urothelium Elicits Urothelial Hyperplasia and Promotes Overexpression of Epidermal Growth Factor Receptor in
Although urothelium is constantly bathed in high concentrations of epidermal growth factor (EGF) and most urothelial carcinomas overexpress EGF receptor (EGFr), relatively little is known about the role of EGFr signaling pathway in urothelial growth and transformation. In the present study, we used the uroplakin II gene promoter to drive the urothelial overexpression of EGFr in transgenic mice....
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Next-generation sequencing (NGS) of human bladder cancer has revealedmany gene alterations compared with normal tissue, with most being predicted to be "loss of function." However, given the high number of alterations, evaluating the functional impact of each is impractical. Here, we develop and use a highthroughput, in vivo strategy to determinewhich alterations are loss of function in tumor g...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2010
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2010.446