Mild Hypothermia Inhibits Inflammation After Experimental Stroke and Brain Inflammation
نویسندگان
چکیده
منابع مشابه
Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation.
BACKGROUND AND PURPOSE We previously showed that mild hypothermia protects against experimental stroke, even when cooling was delayed by 2 hours. Protection may be due in part to inhibiting inflammation. To clarify, we examined leukocyte infiltration, microglial activation, and adhesion molecule expression in models of stroke and pure brain inflammation. METHODS Rats underwent 2-hour middle c...
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Over the last 50 years deep hypothermia (23 degrees C) has demonstrated to be an excellent neuroprotective agent in cerebral ischemic injury. Mild hypothermia (31-33 degrees C) has proven to have the same neuroprotective properties without the detrimental effects of deep hypothermia. Mechanisms of injury that are exaggerated by moderate hyperthermia and ameliorated by hypothermia include, reduc...
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BACKGROUND Stroke is the second to third leading cause of death. Toll-like receptor 4 (TLR4) is a signaling receptor in innate immunity that is a specific immunologic response to systemic bacterial infection and cerebral injury. The role of TLR4 in brain ischemia has not been examined yet. We have therefore investigated whether cerebral ischemia and inflammation produced by permanent occlusion ...
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ژورنال
عنوان ژورنال: Stroke
سال: 2003
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000091269.67384.e7