Midodrine Efficacy in Orthostatic Hypotension
نویسندگان
چکیده
منابع مشابه
Efficacy of single or combined midodrine and pyridostigmine in orthostatic hypotension.
OBJECTIVE To evaluate the long-term (for up to 3 months) efficacy and safety of single or combined therapy with midodrine and pyridostigmine for neurogenic orthostatic hypotension (OH). METHODS This was a randomized, open-label clinical trial. In total, 87 patients with symptomatic neurogenic OH were enrolled and randomized to receive 1 of 3 treatments: midodrine only, pyridostigmine only, or...
متن کاملEfficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic failure.
The clinical presentation of autonomic failure is orthostatic hypotension. Severely affected patients require pharmacological treatment to prevent presyncopal symptoms or frank syncope. We previously reported in a proof of concept study that pediatric doses of the norepinephrine transporter blockade, atomoxetine, increases blood pressure in autonomic failure patients with residual sympathetic a...
متن کاملEfficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotension: A Randomized Comparison With Midodrine.
UNLABELLED Splanchnic venous pooling is a major hemodynamic determinant of orthostatic hypotension, but is not specifically targeted by pressor agents, the mainstay of treatment. We developed an automated inflatable abdominal binder that provides sustained servo-controlled venous compression (40 mm Hg) and can be activated only on standing. We tested the efficacy of this device against placebo ...
متن کاملHemodynamic effects of midodrine after spaceflight in astronauts without orthostatic hypotension.
INTRODUCTION Orthostatic hypotension and presyncope are common and potentially serious risks for astronauts returning from space. Susceptible subjects fail to generate an adequate adrenergic response to upright posture. The alpha-1 adrenergic agonist, midodrine, may be an effective countermeasure. We tested the hypothesis that midodrine would have no negative hemodynamic effect on healthy astro...
متن کاملOrthostatic hypotension.
A 29-year-old white woman (weight, 1211b; height, 5 ft 6 in.) was referred to the Hypertension Unit of Massachusetts General Hospital in December 1984. She had been athletic and apparently in excellent health until September 1979 when she contracted an upper respiratory tract infection associated with wheezing. She was treated with prednisone for 5 days with resolution of the symptoms but later...
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ژورنال
عنوان ژورنال: Journal of General Internal Medicine
سال: 2014
ISSN: 0884-8734,1525-1497
DOI: 10.1007/s11606-014-3014-7