منابع مشابه
Dopaminergic neurons modulate GABA neuron migration in the embryonic midbrain
INTRODUCTION Neuronal migration is a fundamental process in the development of the central nervous system because neurons eventually dwell in regions distinct from their origin. From ventricular zones, neurons and/or neuronal progenitors navigate along diverse courses, radially and tangentially, to their final destination and integrate into specific brain circuits (Corbin et al., 2001; Hatten, ...
متن کاملDopaminergic neurons modulate GABA neuron migration in the embryonic midbrain.
Neuronal migration, a key event during brain development, remains largely unexplored in the mesencephalon, where dopaminergic (DA) and GABA neurons constitute two major neuronal populations. Here we study the migrational trajectories of DA and GABA neurons and show that they occupy ventral mesencephalic territory in a temporally and spatially specific manner. Our results from the Pitx3-deficien...
متن کاملLocalization of GABA(B) receptors in midbrain monoamine containing neurons in the rat.
The localization of gamma-aminobutyric acid (GABA)(B) receptors in the midbrain of the rat was examined in multiple labeling studies using antibodies directed against the GABA(B) receptor and either tryptophan hydroxylase or tyrosine hydroxylase. Almost all of the serotonergic and dopaminergic cell bodies in the midbrain displayed GABA(B) receptor-like immunoreactivity. Conversely, most neurons...
متن کاملA dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons.
Dopaminergic neurons are subject to a significant background GABAergic input in vivo. The presence of this GABAergic background might be expected to inhibit dopaminergic neuron firing. However, dopaminergic neurons are not all silent but instead fire in single-spiking and burst firing modes. Here we present evidence that phasic changes in the tonic activity of GABAergic afferents are a potentia...
متن کاملAldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons.
Midbrain dopamine neurons are an essential component of the basal ganglia circuitry, playing key roles in the control of fine movement and reward. Recently, it has been demonstrated that γ-aminobutyric acid (GABA), the chief inhibitory neurotransmitter, is co-released by dopamine neurons. Here, we show that GABA co-release in dopamine neurons does not use the conventional GABA-synthesizing enzy...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2014
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn3764