منابع مشابه
Microtubules in cardiac hypertrophy: a mechanical role in decompensation?
Cardiac function relies on the ability of the myocytes to develop force and shorten, as well as on the geometry of the heart, which translates shortening into stroke volume and force per cell into pressure in the lumen of the chambers. The requirements of circulation are met by adjustment of heart rate and power output by the myocytes. The heart adapts acutely to a hemodynamic load by increasin...
متن کاملMicrotubules modulate cardiomyocyte beta-adrenergic response in cardiac hypertrophy.
The role of microtubules in modulating cardiomyocyte beta-adrenergic response was investigated in rats with cardiac hypertrophy. Male Sprague-Dawley rats underwent stenosis of the abdominal aorta (hypertensive, HT) or sham operation (normotensive, NT). Echocardiography and isolated left ventricular cardiomyocyte dimensions demonstrated cardiac hypertrophy in the HT rats after 30 wk. Cardiomyocy...
متن کاملCarvacrol Ameliorates Pathological Cardiac Hypertrophy in Both In-vivo and In-vitro Models
Hypertension-induced left ventricular hypertrophy is the most important risk factor for heart failure. This study aimed at investigating the effects of monoterpenoid phenol, carvacrol, on myocardial hypertrophy using both in-vivo and in-vitro models. Male Wistar rats were divided into the control (Ctl), un-treated hypertrophy (H), and carvacrol-treated hypertrophy gro...
متن کاملCAMTA in Cardiac Hypertrophy
In this issue of Cell, the Calmodulin binding transcription activator 2 (CAMTA2), is shown by Song et al. (2006) to be an indispensable transcription coactivator for cardiac hypertrophy. CAMTA2 is activated by the dissociation of class II histone deacetylase 5 and promotes transcription of genes involved in cardiac hypertrophy through its interaction with Nkx2-5.
متن کاملCardiac hypertrophy in athletes.
The outstanding physical ability of top athletes and the frequency with which world records are broken continue to fascinate layman and physiologist alike. It is generally assumed that such great achievements are the outcome of ever more rigorous and prolonged training programmes, which cause, among other things, adaptation of the heart in various ways. The most prominent of these is left ventr...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1998
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.82.7.828