منابع مشابه
Cytoskeleton: Microtubules get the signal
Investigations of how the cytoskeleton is controlled by Rho GTPase signaling have focused largely on the remodeling of actin. Recent work in fibroblasts shows that microtubules are also subject to regulation by the Rho pathway, and that the signals acting on actin and microtubules can be teased apart.
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reactive oxygen species can damage stem cell DNA and may accelerate clonal evolution from MDS to AML, it remains to be seen if the early use of SD-208 and SCIO-463 small-molecule inhibitors of TBRI and p38 MAPK will result in delayed disease progression and improved survival in MDS. Conflict-of-interest disclosure: The author declares no competing financial interests. ■ REFERENCES 1. Zhou L, Op...
متن کاملMicrotubules get early release
n page 765, Ohzeki et al. present evidence for sequence specificity in assembling chromatin at mammalian centromeres. The sequence requirements imply that construction of centromeric chromatin is more than an epigenetic process. O Centromeric chromatin assembles at AT-rich repeats called ␣ satellite sequences, or alphoids. Type I alphoids contain boxes for the binding of CENP-B, one of several ...
متن کاملMicrotubules get a name
rom the mists of early electron microscopy (EM) images there gradually emerged, during the 1950s and 1960s, long, rod-shaped structures. Various investigators missed them, dismissed them, or called them canaliculi, endoplasmic reticulum, or filamentous elements. Finally Slautterback (1963) and Ledbetter and Porter (1963) gave them a full description, recognized their ubiquity, and bestowed thei...
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M icrotubules were seen fi rst as static struts in EM images (see " Microtubules get a name " < a r t r e f v o l = " 1 6 8 " p g = " 8 5 2 " > JCB 168:852< / a r t r e f >) and then as polymers created from a defi ned protein component (see " The discovery of tubulin " < a r t r e f v o l = " 1 6 9 " p g = " 5 5 2 " > JCB 169:552< / a r t r e f >). It took a series of studies in the 1980s to e...
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ژورنال
عنوان ژورنال: Nature
سال: 1991
ISSN: 0028-0836,1476-4687
DOI: 10.1038/350378a0