منابع مشابه
Microtubule bundling
It was in a greenhouse in Oakland, California in 1989 that I began to question what I thought I knew about the use of transgenes in agriculture. I had been urged to look at some transgenic petunia plants by a company to which I was a scientific advisor. The plants in front of me had deep purple petals with many white segments. Some of the plants had all-white flowers. The white segments and the...
متن کاملActivation of mitotic kinesin by microtubule bundling
Kinesin-5 family members cross-link and slide parallel microtubules of opposite polarity, an activity that is essential for the formation of a bipolar spindle during mitosis. In this issue, Kapitein et al. (Kapitein, L.C., B.H. Kwok, J.S. Weinger, C.F. Schmidt, T.M. Kapoor, and E.J.G. Peterman. 2008. J. Cell Biol. 182:421-428) demonstrate that microtubule cross-linking triggers the conversion o...
متن کاملFission Yeast Scp3 Potentially Maintains Microtubule Orientation through Bundling
Microtubules play important roles in organelle transport, the maintenance of cell polarity and chromosome segregation and generally form bundles during these processes. The fission yeast gene scp3+ was identified as a multicopy suppressor of the cps3-81 mutant, which is hypersensitive to isopropyl N-3-chlorophenylcarbamate (CIPC), a poison that induces abnormal multipolar spindle formation in h...
متن کاملXnf7 Contributes to Spindle Integrity through Its Microtubule-Bundling Activity
Regulation of microtubule dynamics and organization in mitosis by a number of microtubule-associated proteins (MAPs) is required for proper bipolar spindle assembly, yet the precise mechanisms by which many MAPs function are poorly understood. One interesting class of MAPs is known to localize to the nucleus during interphase yet fulfill important spindle functions during mitosis. We have ident...
متن کاملCYK4 Promotes Antiparallel Microtubule Bundling by Optimizing MKLP1 Neck Conformation
Centralspindlin, a constitutive 2:2 heterotetramer of MKLP1 (a kinesin-6) and the non-motor subunit CYK4, plays important roles in cytokinesis. It is crucial for the formation of central spindle microtubule bundle structure. Its accumulation at the central antiparallel overlap zone is key for recruitment and regulation of downstream cytokinesis factors and for stable anchoring of the plasma mem...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 1990
ISSN: 0028-0836,1476-4687
DOI: 10.1038/345674a0