Microscale Bioadhesive Hydrogel Arrays for Cell Engineering Applications
نویسندگان
چکیده
منابع مشابه
Microscale Bioadhesive Hydrogel Arrays for Cell Engineering Applications.
Bioengineered hydrogels have been explored in cell and tissue engineering applications to support cell growth and modulate its behavior. A rationally designed scaffold should allow for encapsulated cells to survive, adhere, proliferate, remodel the niche, and can be used for controlled delivery of biomolecules. Here we report a microarray of composite bioadhesive microgels with modular dimensio...
متن کاملBioadhesive hydrogel microenvironments to modulate epithelial morphogenesis.
Epithelial cells polarize and differentiate into organotypic cell aggregates in response to cell-cell and cell-matrix interactions. For example, Madin-Darby Canine Kidney (MDCK) cells form spherical cell aggregates (cysts) with distinct apical and basolateral polarity when cultured three dimensionally (embedded) in type I collagen gels. To investigate the effects of individual extracellular fac...
متن کاملDropletMicroarray: facile formation of arrays of microdroplets and hydrogel micropads for cell screening applications.
We describe a one-step method for creating thousands of isolated pico- to microliter-sized droplets with defined geometry and volume. Arrays of droplets are instantly formed as liquid moves along a superhydrophilic-superhydrophobic patterned surface. Bioactive molecules, nonadherent cells, or microorganisms can be trapped in the fully isolated microdroplets for high-throughput screening, or in ...
متن کاملMethylcellulose Based Thermally Reversible Hydrogel System for Tissue Engineering Applications
The thermoresponsive behavior of a Methylcellulose (MC) polymer was systematically investigated to determine its usability in constructing MC based hydrogel systems in cell sheet engineering applications. Solution-gel analyses were made to study the effects of polymer concentration, molecular weight and dissolved salts on the gelation of three commercially available MCs using differential scann...
متن کاملGradient Material Strategies for Hydrogel Optimization in Tissue Engineering Applications
Although a number of combinatorial/high-throughput approaches have been developed for biomaterial hydrogel optimization, a gradient sample approach is particularly well suited to identify hydrogel property thresholds that alter cellular behavior in response to interacting with the hydrogel due to reduced variation in material preparation and the ability to screen biological response over a rang...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular and Molecular Bioengineering
سال: 2014
ISSN: 1865-5025,1865-5033
DOI: 10.1007/s12195-014-0353-8