MicroRNAs for Restenosis and Thrombosis After Vascular Injury
نویسندگان
چکیده
منابع مشابه
MicroRNAs for Restenosis and Thrombosis After Vascular Injury.
Percutaneous revascularization revolutionized the therapy of patients with coronary artery disease. Despite continuous technical advances that substantially improved patients' outcome after percutaneous revascularization, some issues are still open. In particular, restenosis still represents a challenge, even though it was dramatically reduced with the advent of drug-eluting stents. At the same...
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Vascular injury induces haemostasis with subsequent thrombus formation. Accumulating evidence indicates that activation of the tissue factor (TF) pathway may play an important role in the pathophysiology of intravascular thrombus formation following arterial injury. A variety of cell types like monocytes, smooth muscle cells, foam cells and endothelial cells express TF in atherosclerotic lesion...
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OBJECTIVES The objective of this prospective study was to evaluate the relation between high lipoprotein(a) levels and thrombotic and restenotic events after coronary stent implantation. BACKGROUND Lipoprotein(a) may promote atherogenesis, coronary thrombosis and restenosis after balloon angioplasty, but the clinical significance remains unclear. METHODS The study included 2,223 consecutive...
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Excessive proliferation of vascular smooth muscle cells (VSMCs) and incomplete re-endothelialization is a major clinical problem limiting the long-term efficacy of percutaneous coronary angioplasty. We tested if dimethylfumarate (DMF), an anti-psoriasis drug, could inhibit abnormal vascular remodeling via NF-E2-related factor 2 (Nrf2)-NAD(P)H quinone oxidoreductase 1 (NQO1) activity. DMF signif...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2016
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.115.308237