MicroRNAs and Autoimmune-Mediated Eye Diseases
نویسندگان
چکیده
منابع مشابه
MicroRNAs in Autoimmune Diseases
Autoimmune diseases (ADs) are featured by body's immune responses being directed towards its own specific target organs or multiple organ systems, causing persistent inflammation and consequent tissue damage. miRNAs are small noncoding RNAs in a size of approximately 22 nt that play important regulatory roles in many organisms by cleavage or translational inhibition of targeted mRNAs. Many miRN...
متن کاملMicroRNAs in autoimmune rheumatic diseases.
The etiology of autoimmune diseases remains largely unknown. In recent years, besides genetic factors, several studies proposed that the epigenome may hold the key to a better understanding of autoimmunity initiation and perpetuation. More specifically epigenetic regulatory mechanisms comprise DNA methylation, a variety of histone modifications, and microRNA (miRNA) activity, all of which act u...
متن کاملObesity and Eye Diseases
Background: Obesity is a chronic metabolic disease that has become an epidemic today. Objective: Although the effects of obesity on the body have been well studied, less is known about obesity and eye health. Methods The present article is a review study. The search was performed using keywords of obesity and eye diseases in PubMed, Scopus, Web of Science databases from 2000 to 2021. Resul...
متن کاملMicroRNAs as potential biomarkers of eye diseases.
As authors, we would like to express our gratitude for the encouraging feedback received after the publication of our editorial “Present and Future of RNA Interference”, recently published in Arch Soc Esp Oftalmol. 2015;90:1–3.1 We agree with the statement that the concept of “one gene, one protein”, regarded until a few years ago as one of the main principles of genetics, has been superseded b...
متن کاملMicroRNAs in Human Diseases: From Autoimmune Diseases to Skin, Psychiatric and Neurodegenerative Diseases
MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation, cell development, cell growth, and apoptosis and that miRNAs are highly expr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2020
ISSN: 2296-634X
DOI: 10.3389/fcell.2020.00818