MicroRNA: Potential for Cancer Detection, Diagnosis, and Prognosis

MicroRNA: Potential for Cancer Detection, Diagnosis, and Prognosis.

The Cancer Diagnosis Program of the National Cancer Institute sponsored a workshop entitled ‘‘MicroRNA: Potential for Cancer Detection, Diagnosis, and Prognosis’’ in Rockville, Maryland on November 28 and 29, 2006. The purpose of this workshopwas to bring together leaders in the microRNA (miRNA) field to discuss the potential for the application ofmiRNAs to translational research, with the ulti...

MicroRNA and Male Infertility: A Potential for Diagnosis

MicroRNA: a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer

Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological malignancies. Despite the technological and medical advances over the past four decades, such as the development of several biological markers (mRNA and proteins biomarkers), the mortality rate of ovarian cancer remains a challenge because of its late diagnosis, which is specifically attributed to low specific...

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis.

In the past several years, the importance of microRNA (miRNA) in cancer cells has been recognized. Proper control of miRNA expression is essential for maintaining a steady state of the cellular machinery. Recently, it was discovered that extracellular miRNAs circulate in the blood of both healthy and diseased patients, although ribonuclease is present in both plasma and serum. Most of the circu...

Imaging, Diagnosis, Prognosis Salivary microRNA: Discovery, Characterization, and Clinical Utility for Oral Cancer Detection

Purpose: We have previously shown that a transcriptome is found in saliva and subpanels of these mRNAs can be used as oral cancer biomarkers. In this study, we measured the presence of microRNAs (miRNA) in saliva and determined their potential as an additional set of oral cancer biomarkers. Experimental Design: A total of 314 miRNAs were measured using reverse transcriptase-preamplification-qua...