MicroRNA let-7, T Cells, and Patient Survival in Colorectal Cancer
نویسندگان
چکیده
منابع مشابه
Regulatory T Cells in Colorectal Cancer
One of the essential protection mechanisms of immune system is Treg cells which play an important role in maintenance ofimmune homeostasis. However, they may also inhibit immune functions against tumor cells. It has been reported that Treg cellsare increased in patients suffering from different types of cancer. Increased number of Treg cells has been shown in tumor lymphnodes, peripheral blood,...
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Objective(s): The rs712 polymorphism in a let-7 microRNA-binding site at KRAS gene has been associated with cancer. To examine its association with rs712 polymorphism, we analyzed Mexican individuals with colorectal cancer (CRC) and healthy subjects. Materials and Methods: Genotyping of the rs712 polymorphism was performed by polymerase chain reaction in 281 controls and 336 CRC patients. Resul...
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The complex interactions between colorectal neoplasia and immune cells in the tumor microenvironment remain to be elucidated. Experimental evidence suggests that microRNA MIR21 (miR-21) suppresses antitumor T-cell-mediated immunity. Thus, we hypothesized that tumor MIR21 expression might be inversely associated with T-cell density in colorectal carcinoma tissue. Using 538 rectal and colon cance...
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Colorectal cancer is one of the most prevalent cancers in the world. It's survival expectancy depends on the time of diagnosis, stage and grade of the tumor, and general condition of the patient. Survival expectancy of this type of cancer reveals the quality of diagnostic and therapeutic services in the community. To improve and standardize the treatment modalities in this field, much resea...
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ژورنال
عنوان ژورنال: Cancer Immunology Research
سال: 2016
ISSN: 2326-6066,2326-6074
DOI: 10.1158/2326-6066.cir-16-0112