منابع مشابه
Title: Opportunities and challenges in delivering influenza vaccine by microneedle patch Running title: Delivering influenza vaccine by microneedle patch
Simple and efficacious delivery methods for influenza vaccines are needed to improve health outcomes and to manage possible pandemics in the United States and globally. One approach to meeting these needs is the microneedle patch (MNP), a small array of micron-scale needles that is applied to the skin like a bandage. Because MNPs do not require a conventional needle and syringe, training requir...
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Influenza virus is a major cause of morbidity and mortality particularly in the immunocompromised host. When compared to the general population, influenzarelated hospitalization rates are four times higher and mortality ten times higher in patients with cancer [1]. The Infectious Diseases Society of America (IDSA) recommends the administration of inactivated influenza vaccine (IIV) annually to ...
متن کاملDissolving microneedle vaccine delivery systems
It iswell-established that the transdermal route is an attractive alternative for minimally-invasive drug delivery. The potential of the skin as a site for vaccine delivery has been demonstrated over the past decade, with research indicating stronger immune responses and improved duration of immunity compared with conventional intramuscular administration. Benefits of this minimally invasive va...
متن کاملLong-term protective immunity from an influenza virus-like particle vaccine administered with a microneedle patch.
Skin vaccination with influenza virus-like particles (VLPs) using microneedles has been shown to induce protection similar to or better than that induced by intramuscular immunization. In this study, we examined the long-term protective efficacy of influenza (H1N1 A/PR/8/34) VLPs after skin vaccination using microneedle patches coated with the vaccine. Microneedle vaccination of mice in the ski...
متن کاملA microneedle patch containing measles vaccine is immunogenic in non-human primates.
Very high vaccination coverage is required to eliminate measles, but achieving high coverage can be constrained by the logistical challenges associated with subcutaneous injection. To simplify the logistics of vaccine delivery, a patch containing micron-scale polymeric needles was formulated to encapsulate the standard dose of measles vaccine (1000 TCID₅₀) and the immunogenicity of the micronee...
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ژورنال
عنوان ژورنال: University of Western Ontario Medical Journal
سال: 2016
ISSN: 2560-8274,0042-0336
DOI: 10.5206/uwomj.v85i2.4149