Microfluidic-assisted bacteriophage encapsulation into liposomes
نویسندگان
چکیده
منابع مشابه
Novel methods for the encapsulation of meglumine antimoniate into liposomes.
The antimonial drug, meglumine antimoniate, was successfully encapsulated in dehydration-rehydration vesicles and in freeze-dried empty liposomes (FDELs). High encapsulation efficiencies (from 28 to 58%) and low weight ratios of lipids to encapsulated antimony (from 1:0.15 to 1:0.3) were achieved. These formulations, contrary to those obtained by conventional methods, can be stored as intermedi...
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Vectamidine is a liposome-forming double-chain cationic amphiphile. The present work was aimed to microscopically study the interactions of Vectamidine liposomes with the human erythrocyte plasma membrane. Vectamidine rapidly induced stomatocytic shapes. Attachment of Vectamidine liposomes to the erythrocyte induced a strong local invagination of the membrane. This frequently resulted in a comp...
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OBJECTIVE Brucine was encapsulated into stealth liposomes using the ammonium sulfate gradient method to improve therapeutic index. MATERIALS AND METHODS Four brucine stealth liposomal formulations were prepared, which were made from different phosphatidylcholines (PCs) with different phase transition temperatures (T(m)). The PCs used were soy phosphatidylcholine (SPC), dipalmitoyl phosphatidy...
متن کاملActive Drug Loading of Microfluidic-synthesized Liposomes
In this paper, an established method for microfluidic-directed formation of liposomes is combined with in-line sample purification and active drug loading for one-step, continuous flow synthesis of small, nearly monodisperse vesicles containing high concentrations of stably-loaded compounds. Through microfluidic buffer exchange, the presented technique demonstrates the ability to establish a ch...
متن کاملUltrasound-enhanced microfluidic synthesis of liposomes.
BACKGROUND Liposomes have been successfully used as delivery vehicles for anticancer drugs. Both sonication and microfluidic technologies have been used to produce liposomes. The combination of the two methods was evaluated in this study. MATERIALS AND METHODS The microfluidic devices, mainly comprising micro-dispensers and a sonicator, were used to produce liposomal nanoparticles. Sonication...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2018
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2018.04.063