Microfabricated structures for integrated DNA analysis.
نویسندگان
چکیده
منابع مشابه
Microfabricated structures for integrated DNA analysis.
Photolithographic micromachining of silicon is a candidate technology for the construction of high-throughput DNA analysis devices. However, the development of complex silicon microfabricated systems has been hindered in part by the lack of a simple, versatile pumping method for integrating individual components. Here we describe a surface-tension-based pump able to move discrete nanoliter drop...
متن کاملMicrofabricated bioprocessor for integrated nanoliter-scale Sanger DNA sequencing.
An efficient, nanoliter-scale microfabricated bioprocessor integrating all three Sanger sequencing steps, thermal cycling, sample purification, and capillary electrophoresis, has been developed and evaluated. Hybrid glass-polydimethylsiloxane (PDMS) wafer-scale construction is used to combine 250-nl reactors, affinity-capture purification chambers, high-performance capillary electrophoresis cha...
متن کاملAtom Optics Using Microfabricated Structures
We present a novel method for fabricating precisely positioned small openings in thin silicon nitride membranes. Several optical elements for atoms have been constructed, including amplitude diffraction gratings and zone plates, and the results of experiments using these devices are presented. A method for creating a blazed diffraction grating is discussed. PACS: 35.10.-d, 42.25.-p Atom optics ...
متن کاملMicrofabricated optofluidic ring resonator structures.
We describe the fabrication and preliminary optical characterization of rugged, Si-micromachined optofluidic ring resonator (μOFRR) structures consisting of thin-walled SiO(x) cylinders with expanded midsections designed to enhance the three-dimensional confinement of whispering gallery modes (WGMs). These μOFRR structures were grown thermally at wafer scale on the interior of Si molds defined ...
متن کاملMicrofabricated fountain pens for high-density DNA arrays.
We used photolithographic microfabrication techniques to create very small stainless steel fountain pens that were installed in place of conventional pens on a microarray spotter. Because of the small feature size produced by the microfabricated pens, we were able to print arrays with up to 25,000 spots/cm2, significantly higher than can be achieved by other deposition methods. This feature den...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.11.5556