Microbiological Transformations of Δ 6a,10a -Tetrahydrocannabinol
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چکیده
منابع مشابه
Plasma and urine profiles of Δ-tetrahydrocannabinol and its metabolites 11-hydroxy-Δ-tetrahydrocannabinol and 11-nor-9-carboxy-Δ-tetrahydrocannabinol after cannabis smoking by male volunteers to estimate recent consumption by athletes
Since 2004, cannabis has been prohibited by the World Anti-Doping Agency for all sports competitions. In the years since then, about half of all positive doping cases in Switzerland have been related to cannabis consumption. In doping urine analysis, the target analyte is 11-nor-9-carboxy-Δ-tetrahydrocannabinol (THCCOOH), the cutoff being 15 ng/mL. However, the wide urinary detection window of ...
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We have shown in past isobolographic studies that a small amount of Δ-tetrahydrocannabinol (Δ-THC) can enhance morphine antinociception in mice. However, previous studies of the Δ-THC/morphine interaction were performed using normal mice or rats and evaluated acute thermal antinociception. Less is known about cannabinoid and opioid interactions involved in mechanical nociception and in chronic ...
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Argentatin B is a naturally occurring tetracyclic triterpene isolated from Parthenium argentatum x P. tomentosa. It was microbiologically transformed to 16, 24-epoxycycloartan-3alpha, 25-diol, (isoargentatin D), by Nocardia corallina var. taoka ATCC 31338, Mycobacterium species NRRL B3683 and Septomyxa affinis ATCC 6737. The later microbe also produced 16, 24-epoxycycloartan-3beta, 25-diol (arg...
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A screening program was conducted to find microorganisms that modify the synthetic cannabinoid nabilone. After purification, the products from three cultures were analyzed by spectral methods to determine their chemical structures. An optically active 9S-hydroxy-6aR,10aR-trans cannabinoid was isolated from a culture of an unidentified soil bacterium designated A24007. From Bacillus cereus cultu...
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The endocannabinoid signalling system is widely accepted to play a role in controlling the affective state. Plant cannabinoids are well known to have behavioural effects in animals and humans and the cannabinoid CB(1) receptor antagonist rimonabant has recently been shown to precipitate depression-like symptoms in clinical trial subjects. The aim of the present study was to investigate the beha...
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ژورنال
عنوان ژورنال: Applied and Environmental Microbiology
سال: 1977
ISSN: 0099-2240,1098-5336
DOI: 10.1128/aem.33.5.1134-1140.1977