Microbial transformation of lovastatin by Beauveria bassiana
نویسندگان
چکیده
منابع مشابه
Transformations of steroids by Beauveria bassiana.
The course of transformations of testosterone and its derivatives, including compounds with an additional C1,C2 double bond and/or a 17alpha-methyl group, a 17beta-acetyl group or without a 19-methyl group, by a Beauveria bassiana culture was investigated. The fungi promoted hydroxylation of these compounds at position 11alpha, oxidation of the 17beta-hydroxyl group, reduction of the C1,C2 or C...
متن کاملSuccessful Development of Cordyceps bassiana Stromata from Beauveria bassiana
A specimen of Beauveria bassiana was collected from Yang-yang of Gangwon province, Korea in October 2006. Conidial isolates were prepared from the specimen by the dilution method and inoculated in brown rice medium for fruiting body production. After nearly two months incubation for perithecial stromata developed from single isolates as well as from their combinations. They were determined as C...
متن کاملMICROBIAL TRANSFORMATION OF CHOLESTEROL BY MYCOBACTERIUM SMEGMATIS
Mycobacterium smegmatis PTCC 1307 (CIP 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. The side chain of cholesterol, as the substrate, was selectively cleaved in the presence of five enzyme inhibitors. An intermediate structure with intact side chain, cholest-4-ene-3-one, ...
متن کاملSpecific 5-hydroxylation of piperlongumine by Beauveria bassiana ATCC 7159.
A new hydroxylated derivative was efficiently prepared by transforming the natural anti-cancer product, piperlongumine, with Beauveria bassiana ATCC 7159. Its structure was determined to be 5-hydroxylpiperlongumine on the basis of the spectroscopic data. The absolute configuration at C-5 was established as R by Mosher's method.
متن کاملMedical management of Beauveria bassiana keratitis.
PURPOSE To describe a case of Beauveria bassiana keratitis and to discuss the management of this rare condition. METHODS An 82-year-old woman underwent surgical repair of a graft wound dehiscence. Seven months later, shortly after the removal of sutures, the patient developed a fungal keratitis. B. bassiana was identified as the infecting organism. The patient was treated with topical natamyc...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2012
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2012.04.001