منابع مشابه
Prions by activation not amyloid
ells that passively swell and contract with changes in osmolarity are the key to detecting those changes, say Most cells have at least two mechanisms for maintaining homeostasis in response to changes in salt concentrations. Without these mechanisms, osmotic forces take over: more water and thus less salt outside cells leads water to flood into a cell. But this swelling doesn't occur in most ce...
متن کاملMeasuring prions by bioluminescence imaging.
Prions are infectious proteins that cause fatal neurodegenerative diseases. Because astrocytic gliosis marked by the deposition of fibrils composed of GFAP is a prominent feature of prion disease, we asked whether GFAP might be used as a surrogate marker for prions. To interrogate this posit, we inoculated prions into transgenic (Tg) mice expressing luciferase (luc) under the GFAP gene (Gfap) p...
متن کاملPrions.
The discovery of infectious proteins, denoted prions, was unexpected. After much debate over the chemical basis of heredity, resolution of this issue began with the discovery that DNA, not protein, from pneumococcus was capable of genetically transforming bacteria (Avery et al. 1944). Four decades later, the discovery that a protein could mimic viral and bacterial pathogens with respect to the ...
متن کاملPrions.
Infectious proteins (prions) are usually self-templating filamentous protein polymers (amyloids). Yeast prions are genes composed of protein and, like the multiple alleles of DNA-based genes, can have an array of "variants," each a distinct self-propagating amyloid conformation. Like the lethal mammalian prions and amyloid diseases, yeast prions may be lethal, or only mildly detrimental, and sh...
متن کاملPrions
plants are cloaked in hundreds of tiny projections, known as trichomes. These structures vary in function, shape, size and spacing from species to species, and it’s not known whether similar cellular differentiation programs are responsible for making trichomes in different plants. Trichomes are clearly visible in the scanning electron micrograph of a wild-type Nicotiana tabacum seedling above ...
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ژورنال
عنوان ژورنال: Prion
سال: 2018
ISSN: 1933-6896,1933-690X
DOI: 10.1080/19336896.2018.1469945