Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research
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چکیده
منابع مشابه
Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research
Plants produce a variety of secondary metabolites that possess strong physiological activities. Unfortunately, however, their production can suffer from a variety of serious problems, including low levels of productivity and heterogeneous quality, as well as difficulty in raw material supply. In contrast, microorganisms can be used to produce their primary and some of their secondary metabolite...
متن کاملThe biosynthesis of plant alkaloids and nitrogenous microbial metabolites.
The biosynthesis of plant alkaloids and related nitrogenous microbial secondary metabolites is reviewed. This involves discussion of the outcome of studies with isotopic labels and of genetic and enzymic experiments. The review follows on from a similar, earlier account [Nat. Prod. Rep., 2001, 18, 50-65], covers the literature for the calendar years 1999 and 2000, and contains 143 references.
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Plants are eminent source of new therapeutic agents that helps to alleviate human ailments and promote health. The noteworthy preventive and protective properties of these substances are related to their strong antioxidative, antimutagenic and anticarcinogenic potential. Among these, alkaloids are important secondary metabolites that are known to possess curative properties and are of prime imp...
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Several microorganisms showed the ability to transform the harman alkaloids, harmaline (1), harmalol (2) and harman (5). Harmaline (1) and harmalol (2) were converted by Rhodotorula rubra ATCC 20129 into the tryptamines, 2-acetyl-3-(2-acetamidoethyl)-7-methoxyindole (3) and 2-acetyl-3-(2-acetamidoethyl)-7-hydroxyindole (4), respectively. Harman (5) was biotransformed by Cunninghamella echinulat...
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Microbial secondary metabolites are compounds produced mainly by actinomycetes and fungi, usually late in the growth cycle (idiophase). Although antibiotics are the best known secondary metabolites (SM), there are others with an enormous range of other biological activities mainly in fields like: pharmaceutical and cosmetics, food, agriculture and farming. These include compounds with anti-infl...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 2013
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.89.165