Microbial glycosaminoglycan glycosyltransferases
نویسندگان
چکیده
منابع مشابه
MINI REVIEW Microbial glycosaminoglycan glycosyltransferases
Glycosaminoglycans, a class of linear polysaccharides composed of repeating disaccharide units containing a hexosamine, are important carbohydrates found in many organisms. Vertebrates utilize glycosaminoglycans in structural, recognition, adhesion, and signaling roles. Certain pathogenic bacteria produce extracellular capsules composed of glycosaminoglycans or glycosaminoglycanlike polymers th...
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Various kinds of glycosaminoglycans (GAGs) and proteoglycans (PGs) have been known to be involved in structural and space-filling functions, as well as many physiological regulations in skin. To investigate ultraviolet (UV) radiation-mediated regulation of GAGs and PGs in cultured human dermal fibroblasts, transcriptional changes of many types of PGs and GAG chain-synthesizing enzymes at 18 hr ...
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Legionella causes severe pneumonia in humans. The pathogen produces an array of effectors, which interfere with host cell functions. Among them are the glucosyltransferases Lgt1, Lgt2 and Lgt3 from L. pneumophila. Lgt1 and Lgt2 are produced predominately in the post-exponential phase of bacterial growth, while synthesis of Lgt3 is induced mainly in the lag-phase before intracellular replication...
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Studies of cellular biology in recent decades have highlighted the crucial roles of glycans in numerous important biological processes, raising the concept of glycomics that is now considered as important as genomics, transcriptomics and proteomics. For millions of years, viruses have been co-evolving with their hosts. Consequently, during this co-evolution process, viruses have acquired mechan...
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An N-acetylgalactosaminyltransferase, which converts blood group 0 red blood cells to A cells, was purified to homogeneity from plasma of blood group A, subjects. The enzyme was adsorbed on Sepharose QB, and after washing out the impurities, the enzyme was eluted with UDP. This procedure resulted in a 70,000to lOO,OOO-fold increase in specific activity with recovery of about 80%. Further purifi...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 2002
ISSN: 1460-2423
DOI: 10.1093/glycob/12.1.9r