منابع مشابه
Microbial genomics and infectious diseases.
Copyright © 2011 Massachusetts Medical Society. The pace of technical advancement in microbial genomics has been breathtaking. Since 1995, when the first complete genome sequence of a free-living organism, Haemophilus inf luenzae, was published,1 1554 complete bacterial genome sequences (the majority of which are from pathogens) and 112 complete archaeal genome sequences have been determined, a...
متن کاملHost Genomics in Infectious Diseases
Understanding mechanisms by which genetic variants predispose to complications of infectious diseases can lead to important benefits including the development of biomarkers to prioritize vaccination or prophylactic therapy. Family studies, candidate genes in animal models, and the absence of well-defined risks where the complications are rare all can point to genetic predisposition. The most co...
متن کاملComparative genomics and host resistance against infectious diseases.
The large size and complexity of the human genome have limited the identification and functional characterization of components of the innate immune system that play a critical role in front-line defense against invading microorganisms. However, advances in genome analysis (including the development of comprehensive sets of informative genetic markers, improved physical mapping methods, and nov...
متن کاملMicrobial Translocation and Infectious Diseases: What Is the Link?
The lumen of the gastrointestinal (GI) tract is a complex ecosystem where an enormous quantity of different bacterial species, termed the microbiota, establishes a generally sym-biotic relationship with host immune system and epithelial cells. The correct interaction of the components of the GI tract permits the normal function of this ecosystem, reduces the risk of an excess of microbial trans...
متن کاملCorticosteroids in Infectious Diseases
Accumulated data based on experiences with curtico,teroids in the management uf infectious diseases, have proved that they are very dfective and ,afe drugs provided that are administered properly. The Corticosteroids arc administered mainly bec,1usc o; antitoxic, antiimflammatory a11d antiallcrgic effects, the cndotoxius are ncuturalized, generalized body reactions are diminished, damaged t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2011
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmra1003071