Microbial Efflux Pump Inhibition: Tactics and Strategies

Inhibition of quorum sensing and efflux pump system by trifluoromethyl ketone proton pump inhibitors.

BACKGROUND One major microbiological problem is the widespread antibiotic resistance. There is an urgent need for new antibiotics and ways to treat multi-drug-resistant infections. Inhibition of bacterial quorum sensing (QS) systems could be an effective alternative in a smuch as they regulate a broad spectrum of cell functions, including, virulence factor production, biofilm organisation and m...

Recent advances toward a molecular mechanism of efflux pump inhibition

Multidrug resistance (MDR) in Gram-negative pathogens, such as the Enterobacteriaceae and Pseudomonas aeruginosa, poses a significant threat to our ability to effectively treat infections caused by these organisms. A major component in the development of the MDR phenotype in Gram-negative bacteria is overexpression of Resistance-Nodulation-Division (RND)-type efflux pumps, which actively pump a...

PADUA Protocol: Strategies and Tactics

In this paper we describe an approach to classifying objects in a domain where classifications are uncertain using a novel combination of argumentation and data mining. Classification is the topic of a dialogue game between two agents, based on an argument scheme and critical questions designed for use by agents whose knowledge of the domain comes from data mining. Each agent has its own set of...

Microbial multidrug efflux: introduction.

Evaluation of Efflux pump activity among Uropathogenic Escherichia coli and Klebsiella pneumonia multiple- Drug Resistance isolates

Antibiotic resistance is a phenomenon in which antibiotic used to treat bacteria becomes useless due to resistance mechanism. Increased drug resistance and occurrence of Multiple Drug Resistance in bacteria specificity nosocomial and Urinary Tract Infection bacteria has reduced the possibilities of treating these infectious diseases. Efflux pumps are one of the major mechanism of MDR in bacteri...