Microbial-Derived Butyrate: An Oncometabolite or Tumor-Suppressive Metabolite?
نویسندگان
چکیده
منابع مشابه
Microbial metabolite butyrate facilitates M2 macrophage polarization and function
Metabolites from intestinal microbes modulate the mucosal immune system by regulating the polarization and expansion of T cells. Whether the microbial metabolites influence macrophage polarization, however, is poorly understood. Here, we show that the large bowel microbial fermentation product, butyrate, facilitates M2 macrophage polarization, in vitro and in vivo. The supernatant from butyrate...
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Whether dietary fi ber intake reduces colorectal cancer risk remains controversial, possibly because epidemiologic studies have not controlled for gut microbiota composition. Bacteria in the colon convert fi ber into metabolites such as butyrate, which serves as the primary energy source for normal colonocytes but also inhibits histone deacetylases (HDAC) to epigenetically regulate gene express...
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Short-chain fatty acids (SCFAs), which are generated by the bacterial fermentation of dietary fibers, promote expansion of regulatory T cells (Tregs). Potential therapeutic value of SCFAs has been recently highlighted in the experimental models of T cell-mediated autoimmunity and allergic inflammation. These studies suggest that physiological intestinal concentrations of SCFAs within the millim...
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INTRODUCTION Hyporesponsiveness of human lamina propria immune cells to microbial and nutritional antigens represents one important feature of intestinal homeostasis. It is at least partially mediated by low expression of the innate response receptors CD11b, CD14, CD16 as well as the cystine-glutamate transporter xCT on these cells. Milieu-specific mechanisms leading to the down-regulation of t...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2014
ISSN: 1931-3128
DOI: 10.1016/j.chom.2014.07.011