Microbial conversion of compactin (ML-236B) to ML-236A.
نویسندگان
چکیده
منابع مشابه
ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium.
Sir: Clinical and nutritional studies have indicated that high cholesterol levels in the blood may be one of the major causes of atherosclerosis and coronary heart disease. In this context the metabolism of cholesterol in liver is of paramount importance because liver seems to be the sole organ supplying serum cholesterol and because the conversion of cholesterol into bile acids in liver is qua...
متن کاملFormation of dihydroxy derivative of ML-236B from ML-236B (compactin) by lipid peroxidation.
monooxygenase system in Strepiomyces carbophilus that hydroxylates sodium ML-236B-carboxylate to pravastatin6). Dihydroxy derivative of ML-236B is also obtained in case of S. carbophilus. At first, we determined whether the formation of dihydroxy derivative of ML-236Bdepends upon cytochrome P-450sca monooxygenase or not. According to that paper, S. carbophilus was cultured and cytochrome P-450s...
متن کاملGrowth inhibition of yeast by compactin (ML-236B) analogues.
Numbers in the parentheses represent relative activity to inhibit rat liver HMG-CoAreductase. The present communication deals with sensitivity of the growth of yeast strains to compactin. Of approximately 300 strains tested, 4 strains, Rhodotorula glutinis H3-9-1, Sporobolomyces salmonicolor WF 188, Aessosporon salmonicolor IFO 1845 and Citeromyces matritensis IFO 0954, were found to be sensiti...
متن کاملTaxonomy of actinomycetes capable of hydroxylation of ML-236B (compactin).
Three actinomycetes having capability of 3 beta-hydroxylation of ML-236B were isolated from soil samples collected in Australia. Strain SANK 62781 was identified as Nocardia autotrophica. Strain SANK 62881 and strain SANK 62981 were identified as new subspecies of N. autotrophica for which the name N. autotrophica subsp. canberrica and N. autotrophica subsp. amethystina are proposed, respective...
متن کاملThe synthesis of compactin (ML-236B) and monacolin K in fungi.
Compactin (ML-236B) and monacolin K (mevinolin) are specific inhibitors of 3-hydroxy3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol biosynthetic pathway1~7). ML-236B was isolated from Penicillium citrinuml) and Penicillium brevicompactum2), and monacolin K from Monascus ruber4) and Aspergillus terreus6). In the present study, approximately 4,000 newly is...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1986
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.39.1574