Microarrays and toxicology: The advent of toxicogenomics
نویسندگان
چکیده
منابع مشابه
Microarrays and toxicology: the advent of toxicogenomics.
The availability of genome-scale DNA sequence information and reagents has radically altered life-science research. This revolution has led to the development of a new scientific subdiscipline derived from a combination of the fields of toxicology and genomics. This subdiscipline, termed toxicogenomics, is concerned with the identification of potential human and environmental toxicants, and the...
متن کاملToxicogenomics in the Evolution of Toxicology
Advances in new molecular technologies have promoted the rapid development of toxicogenomics, which aims at understanding the response of the entire genome of an organism to toxicants/toxins. The primary goals of toxicogenomics are to understand the relationship between environmental stress and human disease susceptibility; to explore the molecular mechanisms of toxicants/toxins, and to identif...
متن کاملFunctional Toxicogenomics: Mechanism-Centered Toxicology
Traditional toxicity testing using animal models is slow, low capacity, expensive and assesses a limited number of endpoints. Such approaches are inadequate to deal with the increasingly large number of compounds found in the environment for which there are no toxicity data. Mechanism-centered high-throughput testing represents an alternative approach to meet this pressing need but is limited b...
متن کاملToxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies.
The unprecedented advances in molecular biology during the last two decades have resulted in a dramatic increase in knowledge about gene structure and function, an immense database of genetic sequence information, and an impressive set of efficient new technologies for monitoring genetic sequences, genetic variation, and global functional gene expression. These advances have led to a new sub-di...
متن کاملUshering in the New Toxicology: Toxicogenomics and the Public Interest
New scientific tools spawned by the genomics revolution promise to improve our ability to identify causative factors in human diseases. But as these new tools elucidate the complex interactions between chemical toxins and biologic systems, the strain on traditional ways of understanding toxic effects grows. Despite major advances in the science and technology of these new toxicogenomics tools, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Carcinogenesis
سال: 1999
ISSN: 0899-1987,1098-2744
DOI: 10.1002/(sici)1098-2744(199903)24:3<153::aid-mc1>3.0.co;2-p