منابع مشابه
A Liquid Chromatography – Mass Spectrometry Method for the Determination of Alpha-Ketoglutaric Acid in Human Plasma
Alpha-ketoglutaric acid (A-KG) is currently under investigation as promising cancer cell damaging agent and cyanide antidote. A simple, specific liquid chromatography-mass spectrometry (LC-MS/MS) method was developed for the quantitative determination of A-KG in human plasma. Derivatization of A-KG was achieved by using N-methyl imidazole in presence of trifluroacetic anhydrate. Several paramet...
متن کاملPurification studies of tyrosine-alpha-ketoglutaric acid transaminase.
Recent studies in vitro of tyrosine metabolism have revealed the distribution and the r&e of the tyrosine-a-ketoglutaric acid transaminase system (l-8). In certain of these studies the obligatory rBle of this transaminase as a first step in the conversion of tyrosine to homogentisic acid has been indicated (6-S). The present study is concerned with the partial purification of dog liver tyrosine...
متن کاملCCXXXIII. METABOLISM OF a-KETOGLUTARIC ACID IN ANIMAL TISSUES
DEWAN [1938] and Adler et al. [1939] reported that certain enzyme preparations obtained from heart muscle bring about a reductive amination of ac-ketoglutaric acid. The hydrogen required in this reaction may be provided from other dehydrogenase systems via coenzyme I or II, especially from the ,-hydroxybutyric and i8ocitric dehydrogenases, according to the schemes: (1) ac-ketoglutaric acid+NH3+...
متن کاملVoltammetric Determination of α-Lipoic Acid using Poly(Vanillin) Modified Platinum Electrode
In the present study electrochemical detection of α-lipoic acid (α-LA) was carried out with a poly(Vanillin) modified platinum electrode p(VA)/PtE in Brinton Robinson buffer (BR) solution. The platinum electrode surface’s was modified with cyclic voltammetry method. The prepared Pt electrode was characterized by cyclic voltammetry in ferrocyanide and scanning electron microscopy (SEM) images. T...
متن کاملUrinary excretion of pyruvic acid, alpha-ketoglutaric acid and oxaloacetic acid in scurvy.
Scurvy is associated with abnormal carbohydrate metabolism and diminished production of insulin (1). Banerjee et al. (2) observed increased accumulation of citrate, malate, and lactate in the tissues of scorbutic guinea pigs. This was possibly due to the insulin insufficiency associated with scurvy since prolonged injection of insulin to scorbutic guinea pigs diminished the tissue concentration...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1938
ISSN: 0306-3283
DOI: 10.1042/bj0320108