Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.
نویسندگان
چکیده
منابع مشابه
Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.
Platelet-derived growth factor (PDGF) affects the growth, migration, and function in vitro of mesenchymal cells, but little is known about its normal physiological functions in vivo. We show here that mice deficient for PDGF B die perinatally and display several anatomical and histological abnormalities. Kidney glomerular tufts do not form, apparently because of absence of mesangial cells. Inst...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1994
ISSN: 0890-9369
DOI: 10.1101/gad.8.16.1875