“MGMT for pt mgmt”: Is Methylguanine-DNA Methyltransferase Testing Ready for Patient Management?
نویسندگان
چکیده
منابع مشابه
Towards more specific O6-methylguanine-DNA methyltransferase (MGMT) inactivators.
Searching for a novel family of inactivators of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) which is known to bind to the DNA minor groove, we have computationally modelled and synthesised two series of 2-amino-6-aryloxy-5-nitropyrimidines with morpholino or aminodiaryl substituents (potential minor groove binders) at the 4-position. Synthesis of these compounds...
متن کاملO6-methylguanine-DNA methyltransferase (MGMT) Promoter methylation is a rare event in soft tissue sarcoma
BACKGROUND Gene silencing of O6-methylguanine-DNA methyltransferase (MGMT) by promoter methylation improves the outcome of glioblastoma patients after combined therapy of alkylating chemotherapeutic agents and radiation. The purpose of this study was to assess the frequency of MGMT promoter methylation in soft tissue sarcoma to identify patients eligible for alkylating agent chemotherapy such a...
متن کاملO6-Methylguanine-DNA Methyltransferase (MGMT) mRNA Expression Predicts Outcome in Malignant Glioma Independent of MGMT Promoter Methylation
BACKGROUND We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with concomitant and adjuvant temozolomide or temozolomide alone. As DNA-methyltransferases (DNMTs) are the enzymes responsible for setting up and maintaining ...
متن کاملEffects of O-methylguanine-DNA methyltransferase (MGMT) polymorphisms on cancer: a meta-analysis
State Key Laboratory of Genetic Engineering and the MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, People’s Republic of China, Department of Health Toxicology, Shanghai Second Military Medical University, Shanghai 200433, People’s Republic of China and Life Science Institute, Nanchang University, Jiangxi Provinc...
متن کاملExpression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells.
DNA probes prepared from human O6-methylguanine-DNA methyltransferase complementary DNA were hybridized to mRNA isolated from human liver and fifteen human tumor cell lines proficient (Mer+) or deficient (Mer-) in transferase activity. Liver and Mer+ cells contained levels of transferase-specific mRNA that correlated with their transferase activity levels, whereas Mer- cells contained undetecta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Molecular Diagnostics
سال: 2008
ISSN: 1525-1578
DOI: 10.2353/jmoldx.2008.080043