Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
نویسندگان
چکیده
منابع مشابه
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death.
Mitochondrial fusion and fission is a dynamic process critical for the maintenance of mitochondrial function and cell viability. During excitotoxicity neuronal mitochondria are fragmented, but the mechanism underlying this process is poorly understood. Here, we show that Mfn2 is the only member of the mitochondrial fusion/fission machinery whose expression is reduced in in vitro and in vivo mod...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2014
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.201488327