MexXY Multidrug Efflux System Is More Frequently Overexpressed in Ciprofloxacin Resistant French Clinical Isolates Compared to Hospital Environment Ones
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چکیده
منابع مشابه
Detection of DNA Gyrase Mutation and Multidrug Efflux Pumps Hyperactivity in Ciprofloxacin Resistant Clinical Isolates of Pseudomonas aeruginosa
Target modification and reduced drug accumulation are the main resistance mechanisms against fluoroquinolone antibiotics in Pseudomonas aeruginosa. We performed a genotypic characterization of three major Mex multidrug efflux pumps (MexAB-OprM, MexXY-OprM and MexCD-OprJ) in ciprofloxacin resistant clinical isolates of P. aeruginosa, collected from Tehran, Iran this was followed by sequencin...
متن کاملMexXY multidrug efflux system of Pseudomonas aeruginosa
Anti-pseudomonas aminoglycosides, such as amikacin and tobramycin, are used in the treatment of Pseudomonas aeruginosa infections. However, their use is linked to the development of resistance. During the last decade, the MexXY multidrug efflux system has been comprehensively studied, and numerous reports of laboratory and clinical isolates have been published. This system has been increasingly...
متن کاملDetection of Multidrug Resistant Efflux Pumps in Clinical Isolates of E.coli in Tertiary Care Hospital
Fluoroquinolones are widely used in both community and hospital settings. E.coli exhibits multiple resistant mechanisms; recent studies showed that multidrug resistant (MDR) efflux mechanism is most common. The effects of MDR inhibitors of the RND efflux pumps, Reserpine 25 μg/ml and MC 207, 110 (Phe-Arg-beta-naphthylamide (PaβN), Sigma) 25 μg/ml, on the MIC of fluoroquinolones for clinical iso...
متن کاملEvaluation of Phenotypic and Genotypic Expression of Efflux Pumpin Clinical Isolates of Acinetobacter baumannii Resistant to Ciprofloxacin and Gentamicin
Introduction: Acinetobacter baumannii is an important bacteria because of high ability to obtain antibiotic resistance genes and creation of multi-drug resistant strains (MDR). Today, the active efflux pumps has been suggested as one of the most important mechanisms of intrinsic and acquired resistance of antibiotics in bacteria. The aim of this study was Evaluation of phenotypic and genotypic ...
متن کاملdetection of dna gyrase mutation and multidrug efflux pumps hyperactivity in ciprofloxacin resistant clinical isolates of pseudomonas aeruginosa
target modification and reduced drug accumulation are the main resistance mechanisms against fluoroquinolone antibiotics in pseudomonas aeruginosa. we performed a genotypic characterization of three major mex multidrug efflux pumps (mexab-oprm, mexxy-oprm and mexcd-oprj) in ciprofloxacin resistant clinical isolates of p. aeruginosa, collected from tehran, iran this was followed by sequencing a...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2019
ISSN: 1664-302X
DOI: 10.3389/fmicb.2019.00366