METU-SNP: An Integrated Software System for SNPComplex Disease Association Analysis
نویسندگان
چکیده
منابع مشابه
An integrated system for high throughput TaqManTM based SNP genotyping
UNLABELLED We have developed an integrated laboratory information system that allows the flexible handling of pedigree, phenotype and genotype information. Specifically, it includes client applications for an integrated data import from TaqMan typing files, Mendel checking, data export, handling of pedigree and phenotype information and analysis features. AVAILABILITY The SQL source code, sou...
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UNLABELLED The National Agricultural Biotechnology Information Center (NABIC) constructed a web-based database to provide information about 54,310 single nucleotide polymorphisms (SNPs) identified in the seven species in a high-throughput manner. The database consists of three major functional categories: SNP marker search, detailed information viewer and download of SNP sequence. The SNP annot...
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Motivation: Recent improvements in the accessibility of high-throughput genotyping have brought a great deal of attention to association studies for common complex diseases. The two-loci analysis was recently developed (Marchini et al, 2005) but multi-loci analyses are expected to find even stronger disease associations. Results: A novel combinatorial method for finding disease-associated multi...
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Information about small genetic variations in organisms, known as single nucleotide polymorphism (SNPs), is crucial to identify candidate genes that have a role in disease susceptibility, a long-standing research goal in biology. While a number of established public SNP databases are available, the specification of effective techniques for SNP analysis remains an open issue. We describe a secon...
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We developed a system that supports disease association studies to detect genes that may cause complex diseases. The main function of the system is to examine the possibility of each polymorphism being associated with a disease. Another important function is to perform linkage disequilibrium analysis and combine SNPs (Single Nucleotide Polymorphisms) together into LDblocks (Linkage-Disequilibri...
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ژورنال
عنوان ژورنال: Journal of Integrative Bioinformatics
سال: 2011
ISSN: 1613-4516
DOI: 10.1515/jib-2011-187