منابع مشابه
DNA Methylation Profiling Identifies CG Methylation Clusters in Arabidopsis Genes
Cytosine DNA methylation in vertebrates is widespread, but methylation in plants is found almost exclusively at transposable elements and repetitive DNA. Within regions of methylation, methylcytosines are typically found in CG, CNG, and asymmetric contexts. CG sites are maintained by a plant homolog of mammalian Dnmt1 acting on hemi-methylated DNA after replication. Methylation of CNG and asymm...
متن کاملGenome-wide profiling of DNA methylation in human cancer cells.
Global changes in DNA methylation correlate with altered gene expression and genomic instability in cancer. We have developed a methylation-specific digital sequencing (MSDS) method that can assess DNA methylation on a genomic scale. MSDS is a simple, low-cost method that combines the use of methylation-sensitive restriction enzymes with second generation sequencing technology. DNA methylation ...
متن کاملPrognostic markers and DNA methylation profiling in lymphoid malignancies
Bhoi, S. 2017. Prognostic markers and DNA methylation profiling in lymphoid malignancies. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1363. 77 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0053-5. In recent years, great progress has been achieved towards identifying novel biomarkers in lymphoid malignancies, including chronic lymphocytic ...
متن کاملIn-tube DNA methylation profiling by fluorescence melting curve analysis.
BACKGROUND Most PCR assays for detection of 5-methylcytosine in genomic DNA entail a two-step procedure, comprising initial PCR amplification and subsequent product analysis in separate operations that usually require manual transfer. These methods generally provide information about methylation of only a few CpG dinucleotides within the target sequence. METHODS An in-tube methylation assay i...
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ژورنال
عنوان ژورنال: Epigenomics
سال: 2009
ISSN: 1750-1911,1750-192X
DOI: 10.2217/epi.09.31