Method development and validation of simultaneous estimation for Amlodipine besylate and Olmesartan medoxomil by UV- VISIBLE spectrophotometric Method
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چکیده
منابع مشابه
HPLC method development and validation for simultaneous estimation of Olmesartan Medoxomil, Hydrochlorothiazide and Amlodipine Besylate tablets
In the present work for the determination of Olmesartan Medoxomil, Hydrochlorothiazide and Amlodipine a simple, rapid and precise high performance liquid chromatography procedure has been developed and validated. The separation and quantification were achieved on a Cyano C18 column using a mobile phase of filtered and degassed mixture of buffer and acetonitrile in the ratio of 830:170 with of a...
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Nebistar-SA is available for the treatment of stage II hypertension. It contains nebivolol (NV; 5 mg) and amlodipine (AM; 2.5 mg). In the present study, simple, rapid, precise and accurate method for the simultaneous estimation of these drugs have been developed and validated by UV spectrophotometry. The method was validated with respect to its linearity, limit of quantitation (LOQ), limit of d...
متن کاملDevelopment and Validation of a Chromatography Method Using Tandem UV/Charged Aerosol Detector for Simultaneous Determination of Amlodipine Besylate and Olmesartan Medoxomil: Application to Drug-Excipient Compatibility Study
A study was carried out to investigate compatibility of amlodipine besylate and olmesartan medoxomil with a variety of pharmaceutical excipients. Both drugs are antihypertensive agents that can be administered alone, in monotherapy, or in pharmaceutical association. The studies were performed using binary and ternary mixtures, and samples were stored for 3 and 6 months at 40°C under 75% relativ...
متن کاملSimultaneous Estimation of Amlodipine Besylate and Olmesartan Medoxomil in Combined Tablet Dosage Form Using UV-Spectroscopy and Reverse Phase High-Performance Liquid Chromatography Method
Simple, accurate and precise ultraviolet spectrophotometric and reversed-phase high-performance liquid chromatographic (RP-HPLC) methods for simultaneous estimation of amlodipine besylate (AMLO) and olmesartan medoxomil (OLME) in combined tablet dosage form have been developed and validated. Beer’s law was obeyed in the concentration range of 5-70 and 5-60 μg/mL in methanol at 238 nm and 257 nm...
متن کاملStability-indicating method for simultaneous estimation of olmesartan medoxomile, amlodipine besylate and hydrochlorothiazide by RP-HPLC in tablet dosage form.
A simple, specific, accurate and precise stability-indicating reversed-phase high-performance liquid chromatographic method was developed for simultaneous estimation of olmesartan medoxomile (OLME), amlodipine besylate (AMLO) and hydrochlorothiazide (HCTZ) in tablet dosage form. The method was developed using an RP C18 base deactivated silica column (250 × 4.6 mm, 5 µm) with a mobile phase cons...
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ژورنال
عنوان ژورنال: International Journal of Research in Pharmaceutical Sciences
سال: 2020
ISSN: 0975-7538
DOI: 10.26452/ijrps.v11i2.2161