Methacholine inhalation challenge: a shorter, cheaper and safe approach
نویسندگان
چکیده
منابع مشابه
Methacholine inhalation challenge: a shorter, cheaper and safe approach.
Increased nonspecific bronchial hyperresponsiveness to pharmacological agents such as histamine or methacholine (MCh) is a hallmark of asthma. The measurement of airway reactivity is quite sensitive but testing is tedious, and time and money consuming. The present aim was, therefore, to design the shortest possible, yet safe inhalation challenge protocol applicable for a lung function referral ...
متن کاملDevelopment of a methacholine challenge method to minimize methacholine waste.
BACKGROUND The standard 2-min tidal breathing methacholine challenge utilizes 3 mL to produce an output of 0.26 mL per 2 min, resulting in a substantial amount of methacholine being discarded. OBJECTIVE To develop a method with reduced methacholine waste and to compare it to the standard method. METHODS Twelve subjects with mild, well-controlled asthma volunteered for this investigation. Th...
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N-acetylcysteine (NAC) has antioxidant and possibly mucolytic properties. To determine whether NAC could be of benefit in acute bronchoconstriction induced by methacholine, 12 of 24 anaesthetized dogs (group 1) received NAC i.v. (loading dose 150 mg.kg-1, then 20 mg.kg-1.hr-1). The other 12 (group 2) received diluent. Nebulized methacholine (1%) was then inhaled until arterial oxygen tension (P...
متن کاملConflicting methacholine challenge tests.
An 11-year-old boy experienced almost daily wheezing, dyspnea on exertion, and sleep perturbation because of cough. In addition, nadir peak expiratory flow (PEF) was below 100 L/min, which was 30% of predicted (328 L/min),1 compatible with severe persistent asthma.2 After the initiation of therapy with 180 g of albuterol 3 times per day, the patient’s domiciliary PEF rose to 200 L/min and his s...
متن کاملComparison With Methacholine Inhalation in Asthmatics
reactivity (AHR), because of inherent problems with using a pharmacologic agent in epidemiologic surveys. To our knowledge, no studies exist that compare MIC with EVH in known asthmatics. We conducted a prospective, randomized, crossover trial with a group of subjects (n = 16) who met the American Thoracic Society definition of asthma with these objectives: (1) to compare the sensitivity of EVH...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2001
ISSN: 0000-0000,0903-1936
DOI: 10.1183/09031936.01.17100460