Metformin triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma cells by activating AMPK and suppressing mTOR/AKT signaling
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چکیده
منابع مشابه
The Cytotoxic Effects of Eggplant Peel Extract on Human Gastric Adenocarcinoma Cells and Normal Cells
Background and objective: Gastric cancer is the fourth common and the second deadliest cancer worldwide, which the major causes of its prevalence are genetic factors and the lifestyle, such as eating fast foods, physical inactivity, environmental pollution, and other natural factors. Method: This research was performed in human and animal cell bank of Iranian Biological Resource Center, and ...
متن کاملThe Effect of Sodium Nitrite on Induction of Apoptosis in Human Gastric Adenocarcinoma Epithelia (AGS) Cells
To examine the cytocidal effect of sodium nitrite on the cancer cell, we subjected human gastric adenocarcinoma epithelia (AGS) cells to various experimentation following exposure to sodium nitrite, and measured the resulting changes in the levels of cell death, lactate dehydrogenase (LDH) release, and caspase-3, -6, -8, and -9 activities. Our data revealed that, in AGS cells, treatment with ≥6...
متن کاملNanoliposomal formulation of Ecballium elaterium Extract: Cytotoxic Evaluation against Human Gastric Adenocarcinoma (AGS) Cell Line
Objective(s): The aim of this study was to determine cytotoxic effect of nanoliposomal form of lyophilized aqueous extract of Ecballium elaterium fruit on gastric cell line (AGS) using cell viability tests. Methods: An aqueous extract of the fruits of Ecballium elaterium was prepared. Nanoliposomal form was also prepared by thin-film hydration...
متن کاملExtracts of Opuntia humifusa Fruits Inhibit the Growth of AGS Human Gastric Adenocarcinoma Cells
Opuntia humifusa (OHF) has been used as a nutraceutical source for the prevention of chronic diseases. In the present study, the inhibitory effects of ethyl acetate extracts of OHF on the proliferation of AGS human gastric cancer cells and the mode of action were investigated. To elucidate the antiproliferative mechanisms of OHF in cancer cells, the expression of genes related to apoptosis and ...
متن کاملMHY218-induced apoptotic cell death is enhanced by the inhibition of autophagy in AGS human gastric cancer cells.
We previously reported the anticancer effects of MHY218, which is a hydroxamic acid derivative, in HCT116 human colon cancer cells. In the present study, the involvement of autophagy in the MHY218-induced apoptotic cell death of AGS human gastric cancer cells was investigated. MHY218 treatment induced growth inhibition and apoptotic cell death in a concentration- and time-dependent manner. The ...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2019
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.2019.4704