Metformin: direct inhibition of rat ovarian theca-interstitial cell proliferation
نویسندگان
چکیده
منابع مشابه
Effects of resveratrol on proliferation and apoptosis in rat ovarian theca-interstitial cells.
Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction and associated with ovarian theca-interstitial (T-I) cell hyperplasia, hyperinsulinemia, systemic inflammation and oxidative stress. This in vitro study tested whether rat T-I cell growth with or without insulin can be altered by resveratrol, a natural polyphenol with anti-carcinogenic, anti-inflammatory, anti-proliferativ...
متن کاملResveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis
BACKGROUND Polycystic ovary syndrome (PCOS) is characterized by ovarian enlargement, hyperplastic theca compartment and increased androgen production due to, at least in part, excessive expression of several key genes involved in steroidogenesis. Previously, our group has demonstrated that simvastatin, competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase), a rat...
متن کاملMetformin improves ovarian follicle dynamics by reducing theca cell proliferation and CYP-17 expression in an androgenized rat model
BACKGROUND Metformin influences insulin receptor signaling, which might interfere with the proliferation of ovarian follicular structures and steroidogenesis. We hypothesize that reductions in glucose and insulin levels might interfere with CYP-17 expression and histomorphological changes in an androgenized rat model. The aim of this study was to analyze the effect of metformin on CYP-17 expres...
متن کاملProliferation of ovarian theca-interstitial cells is modulated by antioxidants and oxidative stress.
BACKGROUND Maintenance of ovarian homeostasis requires precise regulation of proliferation of thecal- interstitial (T-I) cells. Recent evidence indicates that oxidative stress and antioxidants modulate proliferation of various tissues under both physiological and pathological conditions. This study evaluated the effects of oxidative stress and antioxidants on T-I proliferation. METHODS Rat T-...
متن کاملHeterogeneity of Ovarian Theca and Interstitial Gland Cells in Mice
It has been established that two developmentally and functionally distinct cell types emerge within the mammalian testis and adrenal gland throughout life. Fetal and adult types of steroidogenic cells (i.e., testicular Leydig cells and adrenocortical cells) develop in the prenatal and postnatal period, respectively. Although the ovary synthesizes steroids postnatally, the presence of fetal-type...
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2012
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2012.04.010