منابع مشابه
DNA Replication: Metazoan Sld3 Steps Forward
In yeast, phosphorylation of the Sld3 protein by cyclin-dependent kinases is essential for replication initiation. In metazoans, three potential Sld3 counterparts have emerged. A new study suggests that one of these, Treslin/Ticrr, is the Sld3 ortholog.
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The fundamental unit of DNA replication, the replicon, is governed by a cis-acting replicator sequence and a trans-activating initiator factor. Despite the increased size and complexity of eukaryotic genomes, eukaryotic DNA replication continues to be guided by the fundamental principles and concepts established in the replicon model.
متن کاملDNA replication origins in archaea
DNA replication initiation, which starts at specific chromosomal site (known as replication origins), is the key regulatory stage of chromosome replication. Archaea, the third domain of life, use a single or multiple origin(s) to initiate replication of their circular chromosomes. The basic structure of replication origins is conserved among archaea, typically including an AT-rich unwinding reg...
متن کاملAnalysis of Metazoan DNA Replication Initiation using Drosophila Gene Amplification
Gene amplification in Drosophila follicle cells is an excellent model to study origin specification and developmental regulation of DNA replication in vivo. We mapped all follicle cell amplicons using a comparative genomic hybridization strategy and identified two new amplicons. We determined the precise localization of the origin recognition complex (ORC) on a genome-wide level and observed th...
متن کاملOptimal placement of origins for DNA replication.
DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of proteins lead to variations in the replication time. We analyze these stochastic properties of DNA and derive the positions of origins corresponding to the minimum...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2019
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2019.03.003