Metal Chelators as Anticancer Approach: Part I; Novel 7-Anisidine Derivatives with Multidentate at 7-8 Carbons of Fluoroquinolone Scaffold as Potential Chelator Anticancer and Antilipolytic Candidates

Background: Cancer is one of the greatest troubling maladies currently. It believed that it second reason for death following cardiovascular maladies. Owing to multiplicity its types, stages and genetic basis, there no existing drug cure all types cancer. Resistance present drugs severe adverse effects are other challenges in struggle against In such pursuit, fluoroquinolones (FQs) have potential as antiproliferative compounds due safety, low cost, absence resistance.
 Aims: this study, we aim synthesize biologically active dual anticancer anti-lipase potential. Sixteen were prepared, fully characterized, studied through identification IC50 values highly susceptible cancer cell lines.
 Methods: work concerned with synthesizing belong anti-colorectal activity, owing association between obesity, conduct titration docking experiments validate our hypothesis.
 Results: vitro findings indicated these demonstrated promising activity tested lines micromolar range a potency comparable cisplatin. Compound 11 exhibited approximately doubled compared cisplatin SW620 colorectal line 3.2 μM which proposes FQs potent agents. The synthesized Fluoroquinolone (FQ) further screened their remarkable control molecule orlistat. 9 orlistat pancreatic lipase 0.4 inhibitors.
 Conclusions: derivatives referred ability inhibit Topo II indicates chelation mechanism inhibition emphasized experiments.