Metabolomic profiling of tumor-infiltrating macrophages during tumor growth

Tumor-Infiltrating Macrophages Induce

Tumor Growth Simulation Profiling

Cancer constitutes a condition and is referred to a group of numerous different diseases, that are characterized by uncontrolled cell growth. Tumors, in the broader sense, are described by abnormal cell growth and are not exclusively cancerous. The molecular basis involves a process of multiple steps and underlying signaling pathways, building up a complex biological framework. Cancer research ...

Tumor infiltrating macrophages reduce development of peritoneal colorectal carcinoma metastases.

Macrophages generally constitute a major component of tumor stroma, and possess either tumor growth promoting or inhibiting capabilities. Classically activated macrophages exert cytotoxicity and produce inflammatory cytokines, which limits tumor growth. By contrast, alternatively activated or M2 macrophages induce tumor progression by stimulating angiogenesis and proliferation. Previously we sh...

Tumor-infiltrating macrophages, cancer stem cells and therapeutic responses

While the genetic and epigenetic changes that regulate cell proliferation, survival and/or differentiation are known 'initiators' of tumor development, these events do not occur in isolation but rather, in the context of a diverse organ specific tumor stroma. Of the stromal components, tumor-infiltrating immune cells are a hallmark of most solid tumors, and the presence of varied immune populat...

Vascular endothelial growth factor secretion by tumor-infiltrating macrophages essentially supports tumor angiogenesis, and IgG immune complexes potentiate the process.

Tumor growth requires neoangiogenesis. Members of the vascular endothelial growth factor (VEGF) family play an important role as angiogenic promoters in malignant tumors. Tumor cells and stromal cells are sources of VEGF in the tumor. We tested the relevance of the tumor-infiltrating macrophage (TIM) contribution as a source of VEGF in the tumor environment and the role of the local immune comp...