Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
نویسندگان
چکیده
منابع مشابه
Metabolite concentrations, fluxes, and free energies imply efficient enzyme usage
In metabolism, available free energy is limited and must be divided across pathway steps to maintain a negative ΔG throughout. For each reaction, ΔG is log proportional both to a concentration ratio (reaction quotient to equilibrium constant) and to a flux ratio (backward to forward flux). Here we use isotope labeling to measure absolute metabolite concentrations and fluxes in Escherichia coli,...
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It would not be appropriate for me, as convener of this discussion, to express any forcible opinions about the controversial aspects of metabolite channelling. Moreover, as an outsider in the field, or at best a newcomer to it, I realize that in expressing any view at all I run the risk of exposing my ignorance without much illuminating the subject. I shall simply pose a question, therefore, as...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2016
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.2077