Metabolism of meso-2,3-dimercaptosuccinic acid in lead-poisoned children and normal adults.
نویسندگان
چکیده
منابع مشابه
Metabolism of meso-2,3-dimercaptosuccinic acid in lead-poisoned children and normal adults.
Meso-2,3-dimercaptosuccinic acid (DMSA, or succimer) is an oral chelating agent for heavy-metal poisoning. While studying the urinary elimination of unaltered DMSA, altered DMSA (i.e., its mixed disulfides), and lead in children with lead poisoning, we observed a pattern of urinary drug elimination after meals suggestive of enterohepatic circulation. The excretion of lead in urine patterned the...
متن کاملSafety and efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) in children with elevated blood lead concentrations.
OBJECTIVE To evaluate the safety and efficacy of meso-2,3-dimercaptosuccinic acid in the treatment of children with lead toxicity. DESIGN This was an open-label study in 59 children 12-65-months old, with pretreatment whole-blood lead levels of 25-66 microg/dL, who received 116, 26-28 day courses of oral dimer-captosuccinic acid, while residing either in the Pediatric Clinical Research Unit o...
متن کاملEffects of meso-2,3-dimercaptosuccinic acid, potassium iodide and chlorophyll on lead accumulation in male mice.
OBJECTIVES Lead (Pb) pollution is a serious public health problem all over the world, it especially plays severe damage role in children's health. Apart from reducing lead-induced damages, the decrease of lead accumulation is also critical. This study has been the first attempt to investigate effects of meso-2,3-dimercaptosuccinic acid (DMSA), potassium iodide (KI) and chlorophyll (Chl) on lead...
متن کاملMeso-2,3-dimercaptosuccinic acid in the treatment of occupationally exposed lead workers.
The aim of this study was to evaluate the efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) treatment in workers with increased lead absorption and no overt symptoms of lead poisoning. Seven occupationally lead exposed male workers with blood lead concentrations (PbB) exceeding 50 micrograms/100 ml and a positive calcium disodium ethylenediaminetetraacetate (EDTA) lead mobilization test were ...
متن کاملLead levels in dentine and circumpulpal dentine of deciduous teeth of normal and lead poisoned children.
A method for the preparation of circumpulpal dentine for lead analysis is described. The technique consists of cutting 6oo-,L-thin sections of deciduous teeth, and, utilizing a vice, fracturing off the circumpulpal dentine from the coronal dentine. Both dentine and circumpulpal dentine of teeth of normal American children and previously identified lead-poisoned children were prepared in this fa...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1995
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.95103734