Metabolism-mediated interaction potential of standardized extract of Tinospora cordifolia through rat and human liver microsomes

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Metabolism-mediated interaction potential of standardized extract of Tinospora cordifolia through rat and human liver microsomes

OBJECTIVE Tinospora cordifolia is used for treatment of several diseases in Indian system of medicine. In the present study, the inhibition potential of T. cordifolia extracts and its constituent tinosporaside to cause herb-drug interactions through rat and human liver cytochrome enzymes was evaluated. MATERIALS AND METHODS Bioactive compound was quantified through reverse phase high-performa...

متن کامل

Radioprotective potential of an herbal extract of Tinospora cordifolia.

A preparation of Tinospora cordifolia (RTc) administered i.p. (200 mg/kg b.w.) to strain "A" male mice 1 h before whole body gamma-irradiation was evaluated for its radioprotective efficacy in terms of whole body survival, spleen colony forming units (CFU), hematological parameters, cell cycle progression, and micronuclei induction. Preirradiation treatment with RTc rendered 76.3% survival (30 ...

متن کامل

Chemopreventive potential of Tinospora cordifolia root extract against Aflatoxin

Antioxidant Biochemical Haematological Lipid peroxidation Preventive

متن کامل

Effect of aqueous extract of Tinospora cordifolia on

18 BACKGROUND: The current practice of ingesting phytochemicals to support the immune 19 system or to fight infections is based on centuries-old tradition. Macrophages are involved at all 20 stages of the immune response. The present study focuses on immunostimulant properties of 21 Tinospora cordifolia in circulating macrophages of CCl4 (0.5 ml/kg body weight) intoxicated 22 male albino mice. ...

متن کامل

Investigation of Cyp1a Interaction Potential of Withania Somnifera in Rat and Human Liver Microsomes

Objective: The aim of this study was to investigate CYP1A interaction of crude extracts (ethanolic, methanolic, hydromethanolic & aqueous) of Withania somnifera and its principal phytoconstituents (withaferin-A and withanolide-A) in rat and human liver microsomes. Methods: In vitro study were carried out in both rat & human liver microsomes while, in vivo CYP1A interaction potential was investi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Indian Journal of Pharmacology

سال: 2016

ISSN: 0253-7613

DOI: 10.4103/0253-7613.190758