Metabolic profiling of praziquantel enantiomers
نویسندگان
چکیده
منابع مشابه
The cytotoxicity study of praziquantel enantiomers
Praziquantel (PZQ) is prescribed as a racemic mixture (racemic-PZQ, rac-PZQ), which is composed of (R)-PZQ and (S)-PZQ. In this work, the cytotoxicity of rac-PZQ and its two enantiomers (R)-PZQ and (S)-PZQ on eight cell lines (L-02, HepG2, prf-plc-5, SH-SY5Y, HUVEC, A549, HCT-15, Raw264.7) was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphe-nyltetrazolium bromide and lactate dehydrogenase a...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2014
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2014.05.001