Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease
نویسندگان
چکیده
منابع مشابه
Evolution of mild cognitive impairment in Parkinson disease.
OBJECTIVE We examined the development of Parkinson disease (PD)-mild cognitive impairment (MCI) in patients with newly diagnosed PD over 5 years using recently proposed consensus criteria, and we assessed the reliability of the criteria. METHODS Patients with PD (n = 123) underwent extensive neuropsychological testing at baseline and after 3 (n = 93) and 5 years (n = 59). Two neuropsychologis...
متن کاملCognitive characteristics associated with mild cognitive impairment in Parkinson's disease.
BACKGROUND Cognitive deficits are common in Parkinson's disease (PD), but the range of deficits is variable. The aim of this study was to identify different cognitive subgroups associated with PD. METHODS A broad range of neuropsychological measures and cognitive domains were used in a cluster analysis to identify subgroups of patients. RESULTS Three subgroups of patients were identified. C...
متن کاملCortical thinning associated with mild cognitive impairment in Parkinson's disease.
The aim of this study was to investigate patterns of cortical atrophy associated with mild cognitive impairment in a large sample of nondemented Parkinson's disease (PD) patients, and its relation with specific neuropsychological deficits. Magnetic resonance imaging (MRI) and neuropsychological assessment were performed in a sample of 90 nondemented PD patients and 32 healthy controls. All unde...
متن کاملCerebral Metabolic Differences Associated with Cognitive Impairment in Parkinson’s Disease
PURPOSE To characterize cerebral glucose metabolism associated with different cognitive states in Parkinson's disease (PD) using 18F-fluorodeoxyglucose (FDG) and Positron Emission Tomography (PET). METHODS Three groups of patients were recruited in this study including PD patients with dementia (PDD; n = 10), with mild cognitive impairment (PD-MCI; n = 20), and with no cognitive impairment (P...
متن کاملmetabolic profiling of Parkinson's disease and mild cognitive impairment
BACKGROUND Early diagnosis of Parkinson's disease and mild cognitive impairment is important to enable prompt treatment and improve patient welfare, yet no standard diagnostic test is available. Metabolomics is a powerful tool used to elucidate disease mechanisms and identify potential biomarkers. OBJECTIVES The objective of this study was to use metabolic profiling to understand the pathoeti...
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ژورنال
عنوان ژورنال: Neurology
سال: 2008
ISSN: 0028-3878,1526-632X
DOI: 10.1212/01.wnl.0000304050.05332.9c