Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression
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منابع مشابه
PW01-040 – Definition of polymorphism C3435T MDR1 gene in JIA
Introduction Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic disease in children. Brug of choice is methotrexate (MTX) cytostatic drug from the group of antimetabolites, folic acid antagonists. According to various authors, about 70% of patients receiving therapy with MTX are in remission for the disease. In 1988, MTX was approved FDA (Food and Drug Administration, USA) ...
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Parkinson’s disease (PD) is the most common neurodegenerative disease. Several studies have identified the role of multidrug resistance 1 (MDR1) C3435T genetic polymorphism in PD susceptibility. However, the results still remain inconclusive. The objective of this study was to determine the effect of MDR1 C3435T variant on PD. Eligible case-control articles published between January 2000 and 20...
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BACKGROUND The multidrug resistance gene 1(MDR1) C3435T polymorphism has been reported to be associated with colorectal cancer (CRC) risk in Asians, however the results were inconsistent. Thus, we performed a meta-analysis to generate large-scale evidence on the association between C3435T polymorphism and CRC risk in Asian populations. METHODS The PubMed, Web of Science, Embase, CNKI, and Chi...
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29 Epilepsy is considered one of the major public health problems and could have serious psychological and physical consequences, including mental health disorders, traumatic injury and premature death1. Epilepsy is a chronic and disabling neurologic disorder and affects approximately 1% of the population globally, especially in developing countries1,2. Although good prognosis has been seen in ...
متن کاملEvaluation of the C3435T polymorphism in the MDR1 gene in patients with hepatocellular carcinoma.
INTRODUCTION Considering the high prevalence of liver tumors and the impact on patient survival, a greater understanding of the biological behavior of those tumors if of great importance. The multidrug resistance gene (MDR1) may present as single nucleotide polymorphism (SNP) which can affect the expression and activity of P-glycoprotein (Pgp), and high expression of Pgp has been associated wit...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2005
ISSN: 0306-5251,1365-2125
DOI: 10.1111/j.1365-2125.2005.02392.x