Meta-Analysis of Lowering LDL Cholesterol and its Impact on the Cardiovascular System

Background: By lowering LDL cholesterol levels, the risk of coronary heart disease (CHD) and other serious vascular events can be significantly reduced. In order to prevent cardiovascular illnesses (CVD), mainly disease, LDL-cholesterol (LDL-C) levels must tightly controlled on both a primary secondary level (CHD). Despite fact that patients in prevention experience higher absolute number atherosclerotic (CV) than those CVD, subjects frequently receive little attention when it comes clinical management LDL-C levels. Aim: To summarise research supporting reduction treatments for elderly people. Method: For this meta-analysis, we searched PubMed, GOOGLE SCHOLAR, SCI.HUB, MEDLINE, Embase publications released between January 1, 2017, December 28, 2021. As recommended by 2018 American Academy Cardiology Heart Association guidelines, randomised trials evaluating outcomes an cholesterol-lowering medicine with median follow-up at least 2 years data older (aged 75 years).The search literature source was limited randomized (human being). This comprised 24 from Cholesterol Therapy Trialists' Collaboration meta-analysis plus five trials, used six journals. 21492 (8%) 244090 participants 29 studies, were over age 75. Among them, 11750 (54%) came statin 6209 (28%) ezetimibe 3533 (16%) PCSK9 inhibitor trials. We conducted network meta-analyses statins non treatments. Results: Of 21492(8%) These included A period 6 used. Without statistically differentiating under (085 [078-092]; pinteraction=037), reduced major (n=3519) 26% 1 mmol/L (RR 074 [95% CI 061-089]; p=00019).In patients, there no significant difference RRs (0.82 [0.73-0.91] non-statin (0.67 [0.47-0.95]; pinteraction=0.64) treatment. Reduced persons shown benefit all components composite, including revascularization (080 [066-096], stroke (073 [061-087], myocardial infarction [071-090]. Practical implication: meta analysis improve treatment people withlowering cholesterol. Conclusion: The viability security diminishing more seasoned adults are now supported further provided meta-analysis. cholesterol-bringing down medication, identified as effective observed younger Keywords: LDL, Meta-analysis, Cardiovascular, Cholesterol,Atherosclerosis, Primary prevention.