Meta-Analysis of Genetic Variation in DTNBP1 and General Cognitive Ability
نویسندگان
چکیده
منابع مشابه
Genetic Copy Number Variation and General Cognitive Ability
Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chr...
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Allelic heterogeneity in genetic association meta-analysis: an application to DTNBP1 and schizophrenia.
BACKGROUND/AIMS Meta-analysis of genetic association studies is a useful approach when individual investigations do not yield studywise significant results but the evidence across studies is modest and homogeneous. Current meta-analysis methods account for heterogeneity by down-weighting studies as a function of between-study variance. We contend that current approaches may obscure interesting ...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2010
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2010.09.016