Mesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells

Abstract This work reports the preparation, characterization, and a drug release study of mesoporous silica nanoparticles (MNPSiO 2 ) functionalized with folic acid (FA) loaded Cis-Pt as targeted system to kill glioblastoma cancer cells. The MNPSiO were synthesized by Stöber method using hexadecyltrimethylammonium bromide templating agent, which was finally removed calcination at 550°C. chemically anchored surface carbodiimide reaction. Several physicochemical techniques used for triplicate in vitro test carried out. experimental values fitted different theoretical models find mechanism. cytotoxicity evaluation performed LN 18 cells (human GBM cells). Homogeneous well-defined well-distributed homogeneous porosity obtained. spectroscopic results show proper functionalization nanoparticles; besides, showed high area large pore size. High correlation coefficients Though best Korsmeyer-Peppas kinetic model, Higuchi model adjusted better obtained our system. -FA highly biocompatible, they increased cytotoxic effect them.