Mesoporous Silica Microparticles Enhance the Cytotoxicity of Anticancer Platinum Drugs
نویسندگان
چکیده
منابع مشابه
Mesoporous silica microparticles enhance the cytotoxicity of anticancer platinum drugs.
We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer platinum drugs when the drugs are combined with (or loaded into) one of the two most common types of mesoporous silica materials, MCM-41 or SBA-15. The anticancer drug cisplatin and its isomer transplatin, when loaded on MCM-41 and SBA-15 microparticles, were less cytotoxic to leukemia cells than the drugs a...
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We report on adsorption and release of the anticancer drugs cisplatin and transplatin from mesoporous silica nanomaterials, emphasizing the differences between cisplatin and its much less toxic isomer. Two types of particles, MCM-41 and SBA-15, were used, either as just synthesized or after calcination to remove the templates. The particles were characterized by TEM, nitrogen physisorption, and...
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The present study deals with the synthesis andfunctionalization of mesoporous silica nanoparticles as drug delivery platforms. SBA-15 nanorods with high surface area (1010 m2g-1) were functionalized by post grafting method using 3-mercaptopropyl trimethoxysilane (MPTS). The parent and thiol-functionalized SBA-15 nanorods were used as nanocarriers for an anticancer drug (gemcitabine). The charac...
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ژورنال
عنوان ژورنال: ACS Nano
سال: 2010
ISSN: 1936-0851,1936-086X
DOI: 10.1021/nn9015345