Meropenem: continuous or extended infusion?
نویسندگان
چکیده
منابع مشابه
Continuous infusion of meropenem in critically ill patients: practical considerations
read with interest the article from Chytra and colleagues, who investigated the eff ectiveness and safety of continuous infusion (CI) of meropenem compared with intermittent infusion (II) in a large cohort (n = 240) of critically ill patients [1]. Th ey found that although clinical cure at the end of therapy was similar between the two strategies, micro bio logical success was higher in the CI ...
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OBJECTIVE To test the hypothesis that treatment with cefepime hydrochloride leads to higher incidence of periodic epileptiform discharges compared with treatment with other β-lactams. DESIGN Data from hospital pharmacy databases of patients treated with cefepime or meropenem during a 42-month period (from January 1, 2007, through June 30, 2010) were retrospectively crossed with data from the ...
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This study explored the pharmacokinetics and the pharmacodynamics of continuous-infusion meropenem in a population of pediatric hematopoietic stem cell transplant (HSCT) patients who underwent therapeutic drug monitoring. The relationship between meropenem clearance (CLM) and estimated creatinine clearance (CLCR) was assessed by nonlinear regression. A Monte Carlo simulation was performed to in...
متن کاملContinuous infusion versus intermittent administration of meropenem in critically ill patients.
This prospective crossover study compared the pharmacokinetics of meropenem by continuous infusion and by intermittent administration in critically ill patients. Fifteen patients were randomized to receive meropenem either as a 2 g iv loading dose, followed by a 3 g continuous infusion (CI) over 24 h, or by intermittent administration (IA) of 2 g iv every 8 h (q8h). Each regimen was followed fo...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2020
ISSN: 1364-8535
DOI: 10.1186/s13054-020-02883-w